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KMID : 0380620220540050555
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Korean Journal of Food Science and Technology
2022 Volume.54 No. 5 p.555 ~ p.560
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Cell cycle arrest by Gardenia jasminoides fruit and anti-proliferative activity by its active components in pancreatic cancer PANC-1 cells
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Jeong Ji-Hye
Lee Hwa-Jin
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Abstract
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The ethyl acetate fraction of Gardenia jasminoides fruit (GJF) showed S-phase arrest of cell cycle in pancreatic cancer PANC-1 cells. GJF also reduced the levels of cell cycle regulatory proteins, such as cyclin B1, cyclin D1, and FoxM1, in PANC-1 cells and suppressed cell viability. Furthermore, the cell viability of PANC-1 cells was reduced by geniposide and 4,5-dicaffeoylquinic acid, which were detected in GJF by HPLC analysis. These results suggested that GJF has anti-proliferative activity via cell cycle arrest and regulation of cell cycle-related proteins in PANC-1 pancreatic cancer cells, and these effects of GJF might be partially attributed to geniposide and 4,5-dicaffeoylquinic acid.
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KEYWORD
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Gardenia jasminoides, cell cycle arrest, pancreatic cancer, polyphenol
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